Lebda Medical Journal https://lebmedj.elmergib.edu.ly/index.php/LMJ <p><span class="wz-italic"><span class="wz-bold wz-italic">Lebda Medical Journal is a peer-reviewed, open access journal that aims to publish high quality papers rapidly and freely available to researchers worldwide. </span></span></p> <p><span class="wz-italic"><span class="wz-bold wz-italic">Lebda Medical Journal </span></span>is an Open Access Printed &amp; Online journal, publishing Original Articles, Review Articles, Short Communications and Case Reports in all Medical Pharmaceutical and Biology areas .</p> en-US Shabukres@elmergib.edu.ly (Salem Abukres) Shabukres@elmergib.edu.ly (Salem Abukres) Mon, 15 Jan 2024 16:21:35 +0000 OJS 3.3.0.13 http://blogs.law.harvard.edu/tech/rss 60 Chemistry; is it vital for undergraduate pharmacy students? https://lebmedj.elmergib.edu.ly/index.php/LMJ/article/view/194 <p>Pharmacists learn chemistry during their undergraduate education at pharmacy colleges. Learning Chemistry is not an easy task. However, it helps pharmacists to understand many aspects about drugs. This article aimed to explore attitudes of working pharmacists about chemistry learning.</p> <p>&nbsp;Self-administered questionnaire was distributed, in October 2021, to 40 private community pharmacies in Alkoms city, Libya. Data analysis was conducted by using Excel an SPSS.</p> <p>Thirty pharmacists participated in this study. The response rate was 75%. Most participants were males. Participants admitted that chemistry helps them their daily pharmacy activities, although it was not easy to learn chemistry.</p> <p>There mixed attitudes towards chemistry learning varied according work expertise and gender. Medicinal chemistry and biochemistry were the most beneficial branches of chemistry.</p> Salem H Abukres, Amina M Amimn Copyright (c) 2024 Lebda Medical Journal https://creativecommons.org/licenses/by-nd/4.0 https://lebmedj.elmergib.edu.ly/index.php/LMJ/article/view/194 Mon, 15 Jan 2024 00:00:00 +0000 Docking of various molecules including two NSAIDs as prototypes into the ‎COX-1 enzyme ‎ https://lebmedj.elmergib.edu.ly/index.php/LMJ/article/view/205 <p>Molecular modeling studies for the cyclo-oxygenase isozyme (COX-1) and docking processes in the COX-1 active site pocket is of an importance of research in Today’s world. This is preformed in order to study the inhibition effect of these different compounds to the COX-1 enzyme by using molecular operation environment (MOE) program. Teen different chemical molecules were fitted in the active site pocket of the COX-1 enzyme and optimized in both cases before and after molecular dynamic simulations that is after taking the best conformation of each ligand of these molecules depending upon scoring investigation. The energy gain for the whole system is obtained by the subtraction of the complexed systems energies from the separated ones. The teen neutral (protonated) molecules were studied and show that the compound 3, 7 and 9 under re-optimization process after MD simulation show the best fitting among all studied molecules and their energy gains were -34.2, -40.4 and -41.21 kcal/mol, respectively. In order to know the effect of ionization on the system, The possible ionized compounds 1, 2 and 3 were studied in both the neutral and deprotonated forms. The obtained results show that both compound 1 and 2 show relatively small inhibition once they studied as in their neutral species. The effect of ionization is very clear once they re-optimized in their deprotonated species. The significant enzyme inhibition is noted since their energies gain changed in neutral forms from 14.4 and 27.3 Kcal/mol to 39.7 and 29.4 Kcal/mol of the deprotonated species, respectively.</p> Klefah A. K. Musa‎ Copyright (c) 2024 https://creativecommons.org/licenses/by-nd/4.0 https://lebmedj.elmergib.edu.ly/index.php/LMJ/article/view/205 Tue, 09 Jul 2024 00:00:00 +0000