Effects of cigarette smoking on lipids profile
Abstract
Cigarette smoking is one of the major risk factors in the genesis of coronary atherosclerosis and heart disease. This study aims to investigate the effects of smoking on the lipid profile. 110 healthy male subjects participated in this study, 70 smokers and 40 non-smokers in the age range of 18 and 50 years at medical laboratory department in higher institute of sciences and medical techniques, Mesallata, Libya, total cholesterol (TC), triglycerides (TG), very low density lipoproteins (VLDL) , low density lipoproteins (LDL) and high density lipoproteins (HDL) were measured. The result showed that significant increase levels of TC, TG, VLDL and LDL in smokers group compared to non-smokers group (P < 0.001). While HDL significantly decrease in smokers compared to non-smokers group (P <0.001). In conclusion cigarette smoking has severe adverse effects on lipids profile which includes increasing the levels of TC, TG, LDL and VLDL with a decrease in HDL level. Smoking whether light or heavy equally affects lipid profile levels, this dyslipidemic levels among smokers may provide a mechanism whereby smoking predisposes to greater risk of developing atherosclerotic plaques and chronic heart disease.
References
2007;131:1557-66.
2. Macky J, Crofton J. Tobacco and the developing world. British Medical Bulletin 1996;52(1):206-21.
3. Al-Azzawy LH, Al-Qaicy AG. study about some physiological parameters in smokers. Ibn Al- Haitham J for Pure & Appl 2011;24.
4. Bjartveit K , Tverdal, A. Health consequences of smoking 1–4 cigarettes per day. Tobacco Control 2005.;14(5):315–20.
5. Bhatt, J. Impact of tobacco smoking on coronary risk factor profile. J. Appl. Basic med. 2003; 5: 105- 108.
6. Cuesta C, Sanchez-Muniz FJ. Garcia-Lscuesta, A, Garrido, R., Castro, A., San-Felix et al. Effect of age and cigarette smoking on serum concentrations of lipids and apolipoproteins in a male military population. Atherosclerosis 1989; 80(1); 33-39.
7. Guedes DP, Guedes, JE, Barbosa, DS, de Oliveira, JA. Tobacco use and plasma lipid lipoprotein profile in adolescents. Rev. Assoc. Med Bras 2007; 53(1): 59-63.
8. Arsian E, Yakar T, Yavașoğu, I. The effect of smoking on mean platelet volume and lipid profile in young male subject. Anadolu Kardio Derg 2008; 8(6): 422-425.
9. Mouhamed DH, Ezzaher A, Neffati F, Gaha L, Douki, W, et al. Association between cigarette smoking and dyslipidemia. Immuno-analyse & Biologie SpeÌcialiseÌe; 2013; 28: 195-200.
10. Prabha V, Waheeda S, Meriton , Stanly A. Effect of Tobacco Smoking on Lipid Profile. Indian Journal of Applied Research 2015; 5: 562-564.
11. Yan-Ling Z, Dong-Qing Z, Chang-Quan H, Bi-Rong D. Cigarette smoking and its association with serum lipid/lipoprotein among Chinese nonagenarians/centenarians. Lipids in health and disease 2012; 11: 1-6.
12. Siekmeier R, Wulfroth P, Wieland H, Gross W, Marz W. Low-density lipoprotein susceptibility of in vitro oxidation in healthy smokers and nonsmokers. Clin Chem. 1996; 42:524–30.
13. Aski BS, Kashinath RT, Hundekari IA. Effect of cigarette smoking on blood lipids- A study in Belgaum, Northern Karnataka. India Global Journal of Medical Research 2012; 12: 6.
14. Carr, JJ, Drekter, JJ. “Simplified rapid technique for extraction and determination of serum cholesterol without saponification" Clin Chem. 1956; 2:353-368.
15. Bucolo G, David H. “Quantitative determination of serum triglycerides by use of enzymes" Clin Chem. 1973; 19:475.
16. Lopez virella et al. Cholesterol determination in high density lipoproteins separated by three different method" Clin Chem. 1977;23: 882.
17. Friedewald W T et al. “Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge" Clin Chem. 1972;18: 499-509.
18. Neki, NS. Lipid profile in chronic smokers-A clinical Study. JIACM 2002; 3:51-4.
19. Anandha LS, Anandhi L, Ganesh KP, Saravanan A.. Effect of Intensity of Cigarette Smoking on Haematological and Lipid Parameters, Journal of Clinical and Diagnostic Research. 2014;8(7): 11-13.
20. Dirican, M , Sarandol E, Ulukaya E., Tokullugil HA..Effects of smoking on serum lipid and lipoprotein concentrations and lecithin: cholesterol acyltransferase activity. J Med Invest 1999;46:169- 72.
21. Nesje LA, Mjos OD. Plasma HDLc holesterol and the subclasses HDL2 and HDL3 in smokers and nonsmokers. Artery 1985; 13(1):7-18.
22.Muscat J, Harris R, Haley N, Wynder E. Cigarette smoking and plasma cholesterol. Am Heart J. 1991; 121:141-47.
23. Eliasson B, Mero N, Taskinen M, Smith U. The insulin resistance syndrome and postprandial lipid intolerance in smokers. Atherosclerosis. 1997; 129: 79-88.
24. Suleyman H, Gumustekin K, Taysi S, et al. Beneficial effects of Hippo phae rhamnoides L on nicotine induced oxidative stress in rat blood compared with vitamin E. Biol Pharm Bull 2002;25:1133-6.
25. Khurana M, Sharma D, Khandelwal PD. Lipid profile in smokers and tobacco chewers - a comparative study. J Assoc Physicians India 2000;48:895-7.
26. Baired DD, Wilcox AJ. Cigarette smoking associated with delayed conception. JAMA 1985; 253:2979-2983.
27. Petrauskaite R, Pershagen G, Gurevicius R. Lung cancer near an industrial site in Lithuania with major emissions of airway irritants. Int J Cancer 2002;99:106-111.
