Fresh Frozen Plasma Quality Control at the Al Marj Central Blood Bank, Libya

Abstract

Background:
Fresh frozen plasma (FFP) is a vital blood component used to treat coagulation disorders, and ensuring its quality is essential to prevent transfusion-related complications.

Objectives:
This study aimed to evaluate the quality of FFP prepared at the Al Marj Central Blood Bank, Libya, and to compare the findings with the international standards established by the American Association of Blood Banks (AABB).

Methods:
A cross-sectional study was conducted on 100 FFP bags. Each unit was analyzed for volume, pH, prothrombin time (PT), partial thromboplastin time (PTT), and residual cell counts after thawing, according to AABB procedures.

Results:
The mean FFP volume (193 ± 28 ml) was significantly below the AABB standard of 200–400 ml (p < 0.001). The mean pH (6.9 ± 0.45) and PT (13.7 ± 1.43 s) were within acceptable limits, while the mean PTT (35.6 ± 2.04 s) was slightly above the upper limit of the standard range (25–35 s), suggesting borderline prolongation. Importantly, the mean platelet count (31.1 ± 38.4 ×10⁹/L) exceeded the AABB limit (<5×10⁹/L).

Conclusion:
Although most parameters met AABB standards, the FFP units demonstrated reduced volume and elevated platelet counts, indicating possible inefficiencies in centrifugation and plasma separation processes. Optimization of preparation procedures is recommended to enhance FFP quality and ensure compliance with international standards.