Clinical Evaluation of Pethidine in Vaginal Labor: A Prospective Cohort Study at Soba and Saad Abo Alella University Hospitals.”

Abstract

Abstract

Background: labor divided into three stage, stage one cervical dilated from ( 0-10cm), stage 2 the fetal head begin to descend causing perineal distention and activating somatic nociceptive pathway and stage three the delivery of the placenta, Pethidine is narcotic opioid analgesic pregnancy category C drugs. The aim of the study is to find out if pethidine has a significant role in the vaginal delivery (reducing pain and assistant cervical dilation).

Method: prospective cohort study from Saad Abo Alella University Hospital and Soba University Hospital  including 385 delivered women ,317 didn’t take pethidine and 68 took it.

Results: the severity of labour pain reduced in group given pethidine. The number of contraction was increased comparing before and after pethidine, 56% (2 contractions per 10 minute before giving pethidine) and 74% (3 contractions per 10 minute after giving pethidine). The number of cases converted to section in group of pethidine was 21% compared to 11.7% in group without pethidine. Time consumed in stage 2; for group without pethidine 36.3% (8–20 min) and pethidine group 36.8% (21–45 min). Pain severity decreased significantly after pethidine administration (p < 0.05), while the rate of cesarean section increased compared to placebo.

Conclusion: pethidine reduce the severity of pain and increase the number of contraction but on the other hand increased the length of stage 2 compared to the group without pethidine and also increased the incidence of those referred to cesarean section.