Biomarker Evaluation in Hemodialysis Patients at Al'assabiea Unit, Libya.

Abstract

Background: Chronic kidney disease (CKD) is a progressive and irreversible condition associated with significant morbidity and mortality. Hemodialysis is widely used to remove metabolic waste products and maintain biochemical balance in patients with advanced renal failure. Aims: This study aimed to evaluate the effect of hemodialysis on key biochemical parameters in patients with chronic renal failure at the Al'assabiea Dialysis Unit, Libya.

Methods: A cross-sectional study was conducted including 10 patients with chronic renal failure undergoing regular hemodialysis and 10 healthy controls. Blood samples were collected before and after dialysis sessions. Biochemical parameters including urea, creatinine, glucose, uric acid, electrolytes, and hemoglobin were analyzed using standard laboratory methods. Statistical analysis was performed using SPSS, with p<0.05 considered significant. The p-values were calculated using paired and independent t-tests as appropriate, comparing pre- vs. post-dialysis values within the patient group, and patient values vs. controls.

Results: Hemodialysis resulted in a statistically significant reduction in urea and creatinine levels (p<0.05). Blood glucose levels increased significantly after dialysis (p<0.05). Hemoglobin levels were lower in patients compared to controls. No significant changes were observed in sodium, potassium, or chloride levels.

Conclusion: Hemodialysis is effective in reducing uremic toxins such as urea and creatinine in CRF patients. However, the observed increase in blood glucose highlights the importance of routine monitoring during dialysis sessions. Addressing anemia and ensuring metabolic stability remain essential components of patient management.