The role of beta-adrenergic receptors in the mechanism of action of imipramine in forced swim test.
Abstract
Noradrenaline (NE) is believed to play an important role in the pathophysiology of depression, and in the mechanism of action of antidepressant compounds. Reduction in central postsynaptic beta-adrenoceptors density has been shown to mediate the therapeutic long-term effects of antidepressants. In the current study, acute, sub chronic and chronic administration of either beta-adrenergic agonist (isoprenaline) or antagonist (betaxolol) alone or in combination with an antidepressant drug (imipramine) was used to investigate the role of beta-adrenergic receptors in the antidepressant effect of imipramine. Forced swim test was used as an acute model of depression. Data of this model suggested a strong relationship between the antimobility effect of imipramine and central beta-adrenergic receptors. Changes in β1-adrenergic receptor levels may mediate its activity in this specific animal model of depression. In conclusion, data of the present work suggest that the antidepressant effect of imipramine is most likely mediated at least in part by β1- adrenoceptor downregulation in mice exposed to forced swim test.
References
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14. Zhang HT, Whisler LR, Huang Y, Xiang Y, O'Donnell JM. Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology. 2009;34(4):1067-77.
15. Alhaider AA, Mustafa AA. Acceleration of rat brain beta-adrenoceptor subsensitivity following the coadministration of histamine receptor antagonists with imipramine. Agents and actions. 1989;28(3- 4):153-8.
16. Krause EG, Curtis KS, Davis LM, Stowe JR, Contreras RJ. Estrogen influences stimulated water intake by ovariectomized female rats. Physiology & behavior. 2003;79(2):267-74.
17. Porsolt RD, Le Pichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266(5604):730-2.
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19. Barros HM, Ferigolo M. Ethopharmacology of imipramine in the forced-swimming test: gender differences. Neurosci Biobehav Rev. 1998;23(2):279- 86.
20. Gurpreet Kaur KS. Selective alpha, adrenoceptor blockade produces antidepressant effect in mice. Indian journal of pharmacol. 1998;30(6):394-8.
21. Lenard NR, Gettys TW, Dunn AJ. Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan. The Journal of pharmacology and experimental therapeutics. 2003;305(2):653-9.
22. Przegalinski E, Siwanowicz J, Baran L. Repeated electroconvulsive shock (ECS) reduces the isoprenaline-induced drinking in rats. Polish journal of pharmacology and pharmacy. 1989;41(1):41-4.
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29. Rossetti ZL, Lai M, Hmaidan Y, Gessa GL. Depletion of mesolimbic dopamine during behavioral despair: partial reversal by chronic imipramine. European journal of pharmacology. 1993;242(3):313- 5.
30. Kirby LG, Lucki I. Interaction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5- hydroxyindoleacetic acid in the rat. The Journal of pharmacology and experimental therapeutics. 1997;282(2):967-76.
31. Lopez-Rubalcava C, Lucki I. Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test. Neuropsychopharmacology. 2000;22(2):191-9.
32. Biala G. Antidepressant-like properties of some serotonin receptor ligands and calcium channel antagonists measured with the forced swimming test in mice. Polish journal of pharmacology. 1998;50(2):117-24.
33. Paul IA, Duncan GE, Kuhn C, Mueller RA, Hong JS, Breese GR. Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake. The Journal of pharmacology and experimental therapeutics. 1990;252(3):997-1005.
34. O'Neill KA, Valentino D. Escapability and generalization: effect on 'behavioral despair'. European journal of pharmacology. 1982;78(3):379- 80.
35. Molderings GJ, Fink K, Schlicker E, Gothert M. Inhibition of noradrenaline release via presynaptic 5- HT1B receptors of the rat vena cava. Naunyn- Schmiedeberg's archives of pharmacology. 1987;336(3):245-50.
36. Detke MJ, Johnson J, Lucki I. Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression. Experimental and clinical psychopharmacology. 1997;5(2):107-12.
37. Curtis AL, Pavcovich LA, Valentino RJ. Long-term regulation of locus ceruleus sensitivity to corticotropin-releasing factor by swim stress. The Journal of pharmacology and experimental therapeutics. 1999;289(3):1211-9.
38. Parale MP, Chakravarti S, Kulkarni SK. Evidence of beta-adrenergic involvement in forced swimming- induced behavioural despair of mice. Methods and findings in experimental and clinical pharmacology. 1987;9(1):35-8.
39. Bourin M, Colombel MC, Malinge M, Bradwejn J. Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity.Journal of psychiatry & neuroscience : JPN.
1991;16(4):199-203.
40. Pilc A, Enna SJ. Supersensitive beta-adrenergic
receptors are down-regulated in rat brain by mianserin administration. J Neural Transm. 1987;70(1-2):71-9.
41. Frishman WH, Tepper D, Lazar EJ, Behrman D. Betaxolol: a new long-acting beta 1-selective adrenergic blocker. Journal of clinical pharmacology. 1990;30(8):686-92.
42. Corsi M KT. The relative importance of the time- course of receptor occupancy and response decay on apparent antagonist potency in dynamic assay. . Auton Pharmacol. 2000;20(4):221-7.
43. Holoubek G, Noldner M, Treiber K, Muller WE. Effect of chronic antidepressant treatment on beta- receptor coupled signal transduction cascade. Which effect matters most? Pharmacopsychiatry. 2004;37 Suppl 2:S113-9.
44. Gram LF. Imipramine: a model substance in pharmacokinetic research. Acta psychiatrica Scandinavica Supplementum. 1988;345:81-4.
45. Ullmann U, Lehnfeld R, Bliesath H, Birkel M, Gebbing H, Grave M, et al. Relative bioavailability of imipramine (Tofranil) coated tablets in healthy volunteers. International journal of clinical pharmacology and therapeutics. 2001;39(6):271-6.
46. Cryan JF, Dalvi A, Jin SH, Hirsch BR, Lucki I, Thomas SA. Use of dopamine-beta-hydroxylase- deficient mice to determine the role of norepinephrine in the mechanism of action of
antidepressant drugs. The Journal of pharmacology
and experimental therapeutics. 2001;298(2):651-7.
47. Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends in
pharmacological sciences. 2002;23(5):238-45.
48. Matrisciano F, Scaccianoce S, Del Bianco P, Panaccione I, Canudas AM, Battaglia G, et al. Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine- induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of neurochemistry.
2005;93(5):1345-52.
49. Duncan GE, Knapp DJ, Little KY, Breese GR.
Neuroanatomical specificity and dose dependence in the time course of imipramine-induced beta adrenergic receptor down-regulation in rat brain. The Journal of pharmacology and experimental therapeutics. 1994;271(3):1699-704.
50. Dziedzicka-Wasylewska M, Rogoz Z, Margas W, Dlaboga D, Goralska M. Some behavioural effects of antidepressant drugs are time-dependent. Progress in neuro-psychopharmacology & biological psychiatry. 2001;25(2):373-93.
51. Szmigielski A, Zawilska J, Kondracki K. Isoprenaline-induced changes in type I inhibitor activity as an index of beta-adrenergic receptor subsensitivity. Polish journal of pharmacology and pharmacy. 1984;36(2-3):281-91.
2. Mata DA, Ramos MA, Bansal N, Khan R, Guille C, Di Angelantonio E, et al. Prevalence of Depression
and Depressive Symptoms Among Resident Physicians: A Systematic Review and Meta-analysis. Jama. 2015;314(22):2373-83.
3. Moret C, Briley M. The importance of norepinephrine in depression. Neuropsychiatric disease and treatment. 2011;7(Suppl 1):9-13.
4. To SE, Zepf RA, Woods AG. The symptoms, neurobiology, and current pharmacological treatment of depression. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. 2005;37(2):102-7.
5. Delgado PL, Moreno FA. Role of norepinephrine in depression. J Clin Psychiatry. 2000;61 Suppl 1:5-12.
6. Nutt DJ. Relationship of neurotransmitters to the symptoms of major depressive disorder. J Clin Psychiatry. 2008;69 Suppl E1:4-7.
7. Salamone JD, Cousins MS, Snyder BJ. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci Biobehav Rev. 1997;21(3):341- 59.
8. Delgado PL. Common pathways of depression and pain. J Clin Psychiatry. 2004;65 Suppl 12:16-9.
9. Cottingham C, Wang Q. alpha2 adrenergic receptor dysregulation in depressive disorders: implications for the neurobiology of depression and antidepressant therapy. Neurosci Biobehav Rev. 2012;36(10):2214- 25.
10. Mills PJ, Dimsdale JE. The promise of adrenergic receptor studies in psychophysiologic research II: Applications, limitations, and progress. Psychosomatic medicine. 1993;55(5):448-57.
11. Siever LJ, Davis KL. Overview: toward a dysregulation hypothesis of depression. The American journal of psychiatry. 1985;142(9):1017- 31.
12. Delgado PL, Miller HL, Salomon RM, Licinio J, Heninger GR, Gelenberg AJ, et al. Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants. Psychopharmacol Bull. 1993;29(3):389-96.
13. Crissman AM, Makhay MM, O'Donnell JM. Discriminative stimulus effects of centrally administered isoproterenol in rats: mediation by beta- 1 adrenergic receptors. Psychopharmacology (Berl). 2001;154(1):70-5.
14. Zhang HT, Whisler LR, Huang Y, Xiang Y, O'Donnell JM. Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology. 2009;34(4):1067-77.
15. Alhaider AA, Mustafa AA. Acceleration of rat brain beta-adrenoceptor subsensitivity following the coadministration of histamine receptor antagonists with imipramine. Agents and actions. 1989;28(3- 4):153-8.
16. Krause EG, Curtis KS, Davis LM, Stowe JR, Contreras RJ. Estrogen influences stimulated water intake by ovariectomized female rats. Physiology & behavior. 2003;79(2):267-74.
17. Porsolt RD, Le Pichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266(5604):730-2.
18. Borsini F, Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl). 1988;94(2):147-60.
19. Barros HM, Ferigolo M. Ethopharmacology of imipramine in the forced-swimming test: gender differences. Neurosci Biobehav Rev. 1998;23(2):279- 86.
20. Gurpreet Kaur KS. Selective alpha, adrenoceptor blockade produces antidepressant effect in mice. Indian journal of pharmacol. 1998;30(6):394-8.
21. Lenard NR, Gettys TW, Dunn AJ. Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan. The Journal of pharmacology and experimental therapeutics. 2003;305(2):653-9.
22. Przegalinski E, Siwanowicz J, Baran L. Repeated electroconvulsive shock (ECS) reduces the isoprenaline-induced drinking in rats. Polish journal of pharmacology and pharmacy. 1989;41(1):41-4.
23. Young KA, Holcomb LA, Yazdani U, Hicks PB, German DC. Elevated neuron number in the limbic thalamus in major depression. The American journal of psychiatry. 2004;161(7):1270-7.
24. Kandel E. Principles of neural science. 4th ed ed2000.
25. Millan MJ, Lejeune F, Gobert A. Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agents. Journal of psychopharmacology. 2000;14(2):114-38.
26. Frazer A. Antidepressants. J Clin Psychiatry. 1997;58 Suppl 6:9-25.
27. Weiss J M KC. Animal models of depression and schizophrenia. In:Nemeroff CB, Schatzberg,A.F.(Eds.),, editor. New York: American
Psychiatric Association Press; 1998.
28. Connor TJ, Kelliher P , Harkin A, Kelly JP , Leonard
BE. Reboxetine attenuates forced swim test-induced behavioural and neurochemical alterations in the rat. European journal of pharmacology. 1999;379(2- 3):125-33.
29. Rossetti ZL, Lai M, Hmaidan Y, Gessa GL. Depletion of mesolimbic dopamine during behavioral despair: partial reversal by chronic imipramine. European journal of pharmacology. 1993;242(3):313- 5.
30. Kirby LG, Lucki I. Interaction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5- hydroxyindoleacetic acid in the rat. The Journal of pharmacology and experimental therapeutics. 1997;282(2):967-76.
31. Lopez-Rubalcava C, Lucki I. Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test. Neuropsychopharmacology. 2000;22(2):191-9.
32. Biala G. Antidepressant-like properties of some serotonin receptor ligands and calcium channel antagonists measured with the forced swimming test in mice. Polish journal of pharmacology. 1998;50(2):117-24.
33. Paul IA, Duncan GE, Kuhn C, Mueller RA, Hong JS, Breese GR. Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake. The Journal of pharmacology and experimental therapeutics. 1990;252(3):997-1005.
34. O'Neill KA, Valentino D. Escapability and generalization: effect on 'behavioral despair'. European journal of pharmacology. 1982;78(3):379- 80.
35. Molderings GJ, Fink K, Schlicker E, Gothert M. Inhibition of noradrenaline release via presynaptic 5- HT1B receptors of the rat vena cava. Naunyn- Schmiedeberg's archives of pharmacology. 1987;336(3):245-50.
36. Detke MJ, Johnson J, Lucki I. Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression. Experimental and clinical psychopharmacology. 1997;5(2):107-12.
37. Curtis AL, Pavcovich LA, Valentino RJ. Long-term regulation of locus ceruleus sensitivity to corticotropin-releasing factor by swim stress. The Journal of pharmacology and experimental therapeutics. 1999;289(3):1211-9.
38. Parale MP, Chakravarti S, Kulkarni SK. Evidence of beta-adrenergic involvement in forced swimming- induced behavioural despair of mice. Methods and findings in experimental and clinical pharmacology. 1987;9(1):35-8.
39. Bourin M, Colombel MC, Malinge M, Bradwejn J. Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity.Journal of psychiatry & neuroscience : JPN.
1991;16(4):199-203.
40. Pilc A, Enna SJ. Supersensitive beta-adrenergic
receptors are down-regulated in rat brain by mianserin administration. J Neural Transm. 1987;70(1-2):71-9.
41. Frishman WH, Tepper D, Lazar EJ, Behrman D. Betaxolol: a new long-acting beta 1-selective adrenergic blocker. Journal of clinical pharmacology. 1990;30(8):686-92.
42. Corsi M KT. The relative importance of the time- course of receptor occupancy and response decay on apparent antagonist potency in dynamic assay. . Auton Pharmacol. 2000;20(4):221-7.
43. Holoubek G, Noldner M, Treiber K, Muller WE. Effect of chronic antidepressant treatment on beta- receptor coupled signal transduction cascade. Which effect matters most? Pharmacopsychiatry. 2004;37 Suppl 2:S113-9.
44. Gram LF. Imipramine: a model substance in pharmacokinetic research. Acta psychiatrica Scandinavica Supplementum. 1988;345:81-4.
45. Ullmann U, Lehnfeld R, Bliesath H, Birkel M, Gebbing H, Grave M, et al. Relative bioavailability of imipramine (Tofranil) coated tablets in healthy volunteers. International journal of clinical pharmacology and therapeutics. 2001;39(6):271-6.
46. Cryan JF, Dalvi A, Jin SH, Hirsch BR, Lucki I, Thomas SA. Use of dopamine-beta-hydroxylase- deficient mice to determine the role of norepinephrine in the mechanism of action of
antidepressant drugs. The Journal of pharmacology
and experimental therapeutics. 2001;298(2):651-7.
47. Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends in
pharmacological sciences. 2002;23(5):238-45.
48. Matrisciano F, Scaccianoce S, Del Bianco P, Panaccione I, Canudas AM, Battaglia G, et al. Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine- induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of neurochemistry.
2005;93(5):1345-52.
49. Duncan GE, Knapp DJ, Little KY, Breese GR.
Neuroanatomical specificity and dose dependence in the time course of imipramine-induced beta adrenergic receptor down-regulation in rat brain. The Journal of pharmacology and experimental therapeutics. 1994;271(3):1699-704.
50. Dziedzicka-Wasylewska M, Rogoz Z, Margas W, Dlaboga D, Goralska M. Some behavioural effects of antidepressant drugs are time-dependent. Progress in neuro-psychopharmacology & biological psychiatry. 2001;25(2):373-93.
51. Szmigielski A, Zawilska J, Kondracki K. Isoprenaline-induced changes in type I inhibitor activity as an index of beta-adrenergic receptor subsensitivity. Polish journal of pharmacology and pharmacy. 1984;36(2-3):281-91.
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Published
2017-10-02
How to Cite
The role of beta-adrenergic receptors in the mechanism of action of imipramine in forced swim test. (2017). Lebda Medical Journal, 3(1), 106–113. Retrieved from https://lebmedj.elmergib.edu.ly/index.php/LMJ/article/view/80
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