Roles of β-adrenergic receptors on the mechanism of action of imipramine in chronic mild stress model of depression.
Abstract
The controversy theories of depression lead to several new hypotheses about antidepressant mechanism of action. Our date from the previous work indicated that beta receptors were involved in the mechanism of action of imipramine in the acute mode of depression the forced swim test). Nowadays, the well-established chronic model of depression, the chronic mild stress (CMS), invented by P Willner, is widely used in the screening of antidepressant activity. In this study, the involvement of β-adrenergic receptors in the mechanism of imipramine action was studied. Data from this research indicated that β-adrenergic receptors were not involved not only in the effect of imipramine effect on the reduction of cortisone level that induced by CMS model of depression, but also they had no effects on the effects of imipramine in the state. In conclusion, β-adrenergic receptors could be involved on imipramine activity of motivation enhancing not on the reduction of stress states.
References
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2. Delgado PL. How antidepressants help depression: mechanisms of action and clinical response. J Clin Psychiatry. 2004;65 Suppl 4:25-30.
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4. Delgado PL, Moreno FA. Role of norepinephrine in depression. J Clin Psychiatry. 2000;61 Suppl 1:5-12.
5. Hurst MW, Jenkins CD, Rose RM. The relation of psychological stress to onset of medical illness. Annu Rev Med. 1976;27:301-12.
6. Newport DJ, Stowe ZN, Nemeroff CB. Parental depression: animal models of an adverse life event. Am J Psychiatry. 2002;159(8):1265-83.
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8. Porsolt RD. Animal models of depression: utility for transgenic research. Rev Neurosci. 2000;11(1):53-8.
9. Willner P. Reliability of the chronic mild stress model of depression: A user survey. Neurobiol Stress. 2017;6:68-77.
10. Remus JL, Stewart LT, Camp RM, Novak CM, Johnson JD. Interaction of metabolic stress with chronic mild stress in altering brain cytokines and sucrose preference. Behav Neurosci. 2015;129(3):321-30.
11. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51(1):8-19.
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14. Moreau JL, Jenck F, Martin JR, Mortas P, Haefely WE. Antidepressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats. Eur Neuropsychopharmacol. 1992;2(1):43-9.
15. Hill MN, Froc DJ, Fox CJ, Gorzalka BB, Christie BR. Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo. Eur J Neurosci. 2004;20(3):859-63.
16. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl). 1987;93(3):358-64.
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18. Choleris E, Thomas AW, Kavaliers M, Prato FS. A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field. Neurosci Biobehav Rev. 2001;25(3):235-60.
19. Singer JB HA, Nadeau JH, and Lander ES. Mapping Quantitative Trait Loci for Anxiety in Chromosome Substitution Strains of Mice. Genetics. 2005; 169,:855-62.
20. Crissman AM, Makhay MM, O'Donnell JM. Discriminative stimulus effects of centrally administered isoproterenol in rats: mediation by beta-1 adrenergic receptors. Psychopharmacology (Berl). 2001;154(1):70-5.
21. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res. 2000;886(1-2):172-89.
22. Harkin A, Houlihan DD, Kelly JP. Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine. J Psychopharmacol. 2002;16(2):115-23.
23. Kvarta MD, Bradbrook KE, Dantrassy HM, Bailey AM, Thompson SM. Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses. J Neurophysiol. 2015;114(3):1713-24.
24. Tafet GE, Idoyaga-Vargas VP, Abulafia DP, Calandria JM, Roffman SS, Chiovetta A, et al. Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression. Cogn Affect Behav Neurosci. 2001;1(4):388-93.
25. Bouwknecht JA, van der Gugten J, Hijzen TH, Maes RA, Hen R, Olivier B. Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal. Psychopharmacology (Berl). 2001;153(4):484-90.
26. Westenbroek C, Ter Horst GJ, Roos MH, Kuipers SD, Trentani A, den Boer JA. Gender-specific effects of social housing in rats after chronic mild stress exposure. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27(1):21-30.
27. Kohler U, Rauca C. Effects of BCH 325 (Pro-D-Phe-Pro-Gly) on open field behavior after chronic stress procedure. Peptides. 1992;13(1):141-4.
28. Willner P. Animal models of depression: an overview. Pharmacol Ther. 1990;45(3):425-55.
29. Harro J, Haidkind R, Harro M, Modiri AR, Gillberg PG, Pahkla R, et al. Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment. Eur Neuropsychopharmacol. 1999;10(1):5-16.
30. Strekalova T, Spanagel R, Bartsch D, Henn FA, Gass P. Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology. 2004;29(11):2007-17.
31. Benelli A, Filaferro M, Bertolini A, Genedani S. Influence of S-adenosyl-L-methionine on chronic mild stress-induced anhedonia in castrated rats. Br J Pharmacol. 1999;127(3):645-54.
32. Katz RJ. Animal model of depression: effects of electroconvulsive shock therapy. Neurosci Biobehav Rev. 1981;5(2):273-7.
33. Stout SC, Mortas P, Owens MJ, Nemeroff CB, Moreau J. Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats. Eur J Pharmacol. 2000;401(1):39-46.
34. Shelton RC, Tomarken AJ. Can recovery from depression be achieved? Psychiatr Serv. 2001;52(11):1469-78.
35. Von Frijtag JC, Van den Bos R, Spruijt BM. Imipramine restores the long-term impairment of appetitive behavior in socially stressed rats. Psychopharmacology (Berl). 2002;162(3):232-8.
36. Naranjo CA, Tremblay LK, Busto UE. The role of the brain reward system in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2001;25(4):781-823.
37. Bardo MT. Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Crit Rev Neurobiol. 1998;12(1-2):37-67.
38. Tremblay LK, Naranjo CA, Cardenas L, Herrmann N, Busto UE. Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine. Arch Gen Psychiatry. 2002;59(5):409-16.
39. O'Neill MF, Conway MW. Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice. Neuropsychopharmacology. 2001;24(4):391-8.
40. Fletcher PJ, Korth KM. Activation of 5-HT1B receptors in the nucleus accumbens reduces amphetamine-induced enhancement of responding for conditioned reward. Psychopharmacology (Berl). 1999;142(2):165-74.
41. Papp M, Lappas S, Muscat R, Willner P. Attenuation of place preference conditioning but not place aversion conditioning by chronic mild stress. J Psychopharmacol. 1992;6(3):352-6.
42. Papp M, Muscat R, Willner P. Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress. Psychopharmacology (Berl). 1993;110(1-2):152-8.
43. Strekalova T, Steinbusch HW. Measuring behavior in mice with chronic stress depression paradigm. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):348-61.
44. Di Giovanni G, De Deurwaerdere P, Di Mascio M, Di Matteo V, Esposito E, Spampinato U. Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience. 1999;91(2):587-97.
45. Willner P. Animal models as simulations of depression. Trends Pharmacol Sci. 1991;12(4):131-6.
2. Delgado PL. How antidepressants help depression: mechanisms of action and clinical response. J Clin Psychiatry. 2004;65 Suppl 4:25-30.
3. Salamone JD, Cousins MS, Snyder BJ. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci Biobehav Rev. 1997;21(3):341-59.
4. Delgado PL, Moreno FA. Role of norepinephrine in depression. J Clin Psychiatry. 2000;61 Suppl 1:5-12.
5. Hurst MW, Jenkins CD, Rose RM. The relation of psychological stress to onset of medical illness. Annu Rev Med. 1976;27:301-12.
6. Newport DJ, Stowe ZN, Nemeroff CB. Parental depression: animal models of an adverse life event. Am J Psychiatry. 2002;159(8):1265-83.
7. Abdulrzag F Ahmed RAA-T, Suhera M Aburawi, Shaban E A Saad. The role of beta-adrenergic receptors in the mechanism of action of imipramine in forced swim test. Lebda Medical Journal. 2017;Vol. (3); p.106-113.
8. Porsolt RD. Animal models of depression: utility for transgenic research. Rev Neurosci. 2000;11(1):53-8.
9. Willner P. Reliability of the chronic mild stress model of depression: A user survey. Neurobiol Stress. 2017;6:68-77.
10. Remus JL, Stewart LT, Camp RM, Novak CM, Johnson JD. Interaction of metabolic stress with chronic mild stress in altering brain cytokines and sucrose preference. Behav Neurosci. 2015;129(3):321-30.
11. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51(1):8-19.
12. D'Aquila P, Monleon S, Borsini F, Brain P, Willner P. Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant. Eur J Pharmacol. 1997;340(2-3):121-32.
13. Willner P, Mitchell PJ. The validity of animal models of predisposition to depression. Behav Pharmacol. 2002;13(3):169-88.
14. Moreau JL, Jenck F, Martin JR, Mortas P, Haefely WE. Antidepressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats. Eur Neuropsychopharmacol. 1992;2(1):43-9.
15. Hill MN, Froc DJ, Fox CJ, Gorzalka BB, Christie BR. Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo. Eur J Neurosci. 2004;20(3):859-63.
16. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl). 1987;93(3):358-64.
17. Mormede C, Castanon N, Medina C, Moze E, Lestage J, Neveu PJ, et al. Chronic mild stress in mice decreases peripheral cytokine and increases central cytokine expression independently of IL-10 regulation of the cytokine network. Neuroimmunomodulation. 2002;10(6):359-66.
18. Choleris E, Thomas AW, Kavaliers M, Prato FS. A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field. Neurosci Biobehav Rev. 2001;25(3):235-60.
19. Singer JB HA, Nadeau JH, and Lander ES. Mapping Quantitative Trait Loci for Anxiety in Chromosome Substitution Strains of Mice. Genetics. 2005; 169,:855-62.
20. Crissman AM, Makhay MM, O'Donnell JM. Discriminative stimulus effects of centrally administered isoproterenol in rats: mediation by beta-1 adrenergic receptors. Psychopharmacology (Berl). 2001;154(1):70-5.
21. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res. 2000;886(1-2):172-89.
22. Harkin A, Houlihan DD, Kelly JP. Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine. J Psychopharmacol. 2002;16(2):115-23.
23. Kvarta MD, Bradbrook KE, Dantrassy HM, Bailey AM, Thompson SM. Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses. J Neurophysiol. 2015;114(3):1713-24.
24. Tafet GE, Idoyaga-Vargas VP, Abulafia DP, Calandria JM, Roffman SS, Chiovetta A, et al. Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression. Cogn Affect Behav Neurosci. 2001;1(4):388-93.
25. Bouwknecht JA, van der Gugten J, Hijzen TH, Maes RA, Hen R, Olivier B. Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal. Psychopharmacology (Berl). 2001;153(4):484-90.
26. Westenbroek C, Ter Horst GJ, Roos MH, Kuipers SD, Trentani A, den Boer JA. Gender-specific effects of social housing in rats after chronic mild stress exposure. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27(1):21-30.
27. Kohler U, Rauca C. Effects of BCH 325 (Pro-D-Phe-Pro-Gly) on open field behavior after chronic stress procedure. Peptides. 1992;13(1):141-4.
28. Willner P. Animal models of depression: an overview. Pharmacol Ther. 1990;45(3):425-55.
29. Harro J, Haidkind R, Harro M, Modiri AR, Gillberg PG, Pahkla R, et al. Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment. Eur Neuropsychopharmacol. 1999;10(1):5-16.
30. Strekalova T, Spanagel R, Bartsch D, Henn FA, Gass P. Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology. 2004;29(11):2007-17.
31. Benelli A, Filaferro M, Bertolini A, Genedani S. Influence of S-adenosyl-L-methionine on chronic mild stress-induced anhedonia in castrated rats. Br J Pharmacol. 1999;127(3):645-54.
32. Katz RJ. Animal model of depression: effects of electroconvulsive shock therapy. Neurosci Biobehav Rev. 1981;5(2):273-7.
33. Stout SC, Mortas P, Owens MJ, Nemeroff CB, Moreau J. Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats. Eur J Pharmacol. 2000;401(1):39-46.
34. Shelton RC, Tomarken AJ. Can recovery from depression be achieved? Psychiatr Serv. 2001;52(11):1469-78.
35. Von Frijtag JC, Van den Bos R, Spruijt BM. Imipramine restores the long-term impairment of appetitive behavior in socially stressed rats. Psychopharmacology (Berl). 2002;162(3):232-8.
36. Naranjo CA, Tremblay LK, Busto UE. The role of the brain reward system in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2001;25(4):781-823.
37. Bardo MT. Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Crit Rev Neurobiol. 1998;12(1-2):37-67.
38. Tremblay LK, Naranjo CA, Cardenas L, Herrmann N, Busto UE. Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine. Arch Gen Psychiatry. 2002;59(5):409-16.
39. O'Neill MF, Conway MW. Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice. Neuropsychopharmacology. 2001;24(4):391-8.
40. Fletcher PJ, Korth KM. Activation of 5-HT1B receptors in the nucleus accumbens reduces amphetamine-induced enhancement of responding for conditioned reward. Psychopharmacology (Berl). 1999;142(2):165-74.
41. Papp M, Lappas S, Muscat R, Willner P. Attenuation of place preference conditioning but not place aversion conditioning by chronic mild stress. J Psychopharmacol. 1992;6(3):352-6.
42. Papp M, Muscat R, Willner P. Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress. Psychopharmacology (Berl). 1993;110(1-2):152-8.
43. Strekalova T, Steinbusch HW. Measuring behavior in mice with chronic stress depression paradigm. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):348-61.
44. Di Giovanni G, De Deurwaerdere P, Di Mascio M, Di Matteo V, Esposito E, Spampinato U. Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience. 1999;91(2):587-97.
45. Willner P. Animal models as simulations of depression. Trends Pharmacol Sci. 1991;12(4):131-6.
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Published
2018-10-14
How to Cite
Roles of β-adrenergic receptors on the mechanism of action of imipramine in chronic mild stress model of depression. (2018). Lebda Medical Journal, 5(1), 168–179. Retrieved from https://lebmedj.elmergib.edu.ly/index.php/LMJ/article/view/88
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